Open AccessOral Heparin Prevents Neointimal Hyperplasia After Arterial Injury
Author(s) -
Frederick G.P. Welt,
T. Cooper Woods,
Elazer R. Edelman
Publication year - 2001
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/hc5001.100837
Subject(s) - medicine , neointimal hyperplasia , heparin , restenosis , balloon , stent , angioplasty , urology , anesthesia , surgery
In animal models, heparin delivered as a continuous intravenous infusion or via frequent (BID) subcutaneous dosing inhibits neointimal hyperplasia after balloon injury or stent implantation. However, human trials of subcutaneous heparin after percutaneous intervention have proven ineffective against restenosis. It may be that these failures are due to unfavorable heparin pharmacokinetics. Recently, the drug delivery agent sodium N-[8-(2-hydroxybenzoyl)amino] caprylate (SNAC) has been found to facilitate the gastric absorption of heparin.
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