Mitochondrial Coupling Factor 6 Is Present on the Surface of Human Vascular Endothelial Cells and Is Released by Shear Stress | Zendy

Tomohiro Osanai | Zendy; Satoko Okada | Zendy; Kenichi Sirato | Zendy; Takao Nakano | Zendy; Masayuki Saitoh | Zendy; Koji Magota | Zendy; Ken Okumura | Zendy

Open Access

Mitochondrial Coupling Factor 6 Is Present on the Surface of Human Vascular Endothelial Cells and Is Released by Shear Stress

Author(s) -

Tomohiro Osanai,

Satoko Okada,

Kenichi Sirato,

Takao Nakano,

Masayuki Saitoh,

Koji Magota,

Ken Okumura

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc5001.100832

Subject(s) - umbilical vein , shear stress , immunofluorescence , endothelial stem cell , medicine , endothelium , flow cytometry , cell culture , prostacyclin , antibody , biophysics , microbiology and biotechnology , biochemistry , biology , immunology , in vitro , materials science , composite material , genetics

We showed that mitochondrial coupling factor 6 (CF6), an endogenous inhibitor of prostacyclin synthesis, is present in the systemic circulation as a pressor substance in rats. We investigated the possibility of vascular endothelial cells as a source of circulating CF6.

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