Open AccessIsoform-Specific Effects of Apolipoprotein E on Atherogenesis
Author(s) -
Hiroaki Yoshida,
Alyssa H. Hasty,
Amy S. Major,
Hiroyuki Ishiguro,
Yan Ru Su,
Linda A. Gleaves,
Vladimir R. Babaev,
MacRae F. Linton,
Sergio Fazio
Publication year - 2001
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/hc4801.100034
Subject(s) - medicine , gene isoform , apolipoprotein e , apolipoprotein b , disease , cholesterol , genetics , gene , biology
We recently used a bone marrow-based gene therapy approach to show that small amounts of retrovirus-derived human apolipoprotein E3 (apoE3) produced by macrophages are protective against early atherosclerosis in apoE-deficient mice.
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