Open AccessAntithrombin III Prevents Early Pulmonary Dysfunction After Lung Transplantation in the Dog
Author(s) -
Ángel Salvatierra,
Rafael Guerrero,
Mariano Rodríguez,
Antonio Álvarez,
Fuensanta Soriano,
C. Lόpez-Pedrera,
Rafael Ramı́rez,
Julia Carracedo,
F. LópezRubio,
Javier López-Pujol,
Francisco Velasco
Publication year - 2001
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/hc4801.100032
Subject(s) - medicine , transplantation , lung transplantation , lung , prostacyclin , fissipedia , ischemia , antithrombin , reperfusion injury , anesthesia , vascular resistance , cardiology , hemodynamics , heparin
Ischemia-reperfusion injury with the resulting inflammatory response is a devastating complication of lung transplantation; much of the tissue damage could be diminished by control of the inflammatory response. Recent studies have show that antithrombin III (AT III) has an anti-inflammatory effect in addition to its established role in the regulation of blood coagulation. Thus, we hypothesized that the administration of AT III might help to prevent ischemia-reperfusion injury after lung transplantation.
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