Effects of Angiotensin-Converting Enzyme Inhibition on the Development of the Atrial Fibrillation Substrate in Dogs With Ventricular Tachypacing–Induced Congestive Heart Failure | Zendy

Danshi Li | Zendy; Kaori Shinagawa | Zendy; Li Pang | Zendy; Tack Ki Leung | Zendy; Sophie Cardin | Zendy; Zhiguo Wang | Zendy; Stanley Nattel | Zendy

Open Access

Effects of Angiotensin-Converting Enzyme Inhibition on the Development of the Atrial Fibrillation Substrate in Dogs With Ventricular Tachypacing–Induced Congestive Heart Failure

Author(s) -

Danshi Li,

Kaori Shinagawa,

Li Pang,

Tack Ki Leung,

Sophie Cardin,

Zhiguo Wang,

Stanley Nattel

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc4601.099402

Subject(s) - medicine , heart failure , enalapril , cardiology , atrial fibrillation , angiotensin ii , endocrinology , angiotensin converting enzyme , blood pressure

Atrial structural remodeling creates a substrate for atrial fibrillation (AF), but the underlying signal transduction mechanisms are unknown. This study assessed the effects of ACE inhibition on arrhythmogenic atrial remodeling and associated mitogen-activated protein kinase (MAPK) changes in a dog model of congestive heart failure (CHF).

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