Mitochondrial Abnormalities in Tumor Necrosis Factor-α–Induced Heart Failure Are Associated With Impaired DNA Repair Activity | Zendy

Yun You Li | Zendy; Dexi Chen | Zendy; Simon C. Watkins | Zendy; Arthur M. Feldman | Zendy

Open Access

Mitochondrial Abnormalities in Tumor Necrosis Factor-α–Induced Heart Failure Are Associated With Impaired DNA Repair Activity

Author(s) -

Yun You Li,

Dexi Chen,

Simon C. Watkins,

Arthur M. Feldman

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc4501.098944

Subject(s) - medicine , heart failure , mitochondrial dna , tumor necrosis factor α , tumor necrosis factor alpha , dna damage , dna repair , mitochondrion , necrosis , cardiology , cancer research , pathology , dna , genetics , gene , biology

Recent studies suggest that mutations in cardiac mitochondrial DNA (mtDNA) may contribute to the development of dilated cardiomyopathy. The mechanisms that regulate those mutations, however, remain undefined. Thus, we studied cardiac mtDNA repair mechanisms, mtDNA damage, and mitochondrial structure and function in mice with heart failure secondary to overexpression of TNF-alpha (TNF1.6 mice).

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