Therapeutic Angiogenesis Induced by Human Hepatocyte Growth Factor Gene in Rat Diabetic Hind Limb Ischemia Model
Author(s) -
Yoshiaki Taniyama,
Ryuichi Morishita,
Kazuya Hiraoka,
Motokuni Aoki,
Hironori Nakagami,
Keita Yamasaki,
Kunio Matsumoto,
Toshikazu Nakamura,
Yasufumi Kaneda,
Toshio Ogihara
Publication year - 2001
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/hc4401.098470
Subject(s) - hepatocyte growth factor , angiogenesis , medicine , genetic enhancement , therapeutic angiogenesis , endocrinology , transfection , diabetes mellitus , vascular endothelial growth factor , matrix metalloproteinase , neovascularization , biology , cell culture , gene , receptor , biochemistry , genetics , vegf receptors
Because no study has documented the angiogenic properties of hepatocyte growth factor (HGF) in a diabetes model, we examined the feasibility of gene therapy using HGF to treat peripheral arterial disease in diabetes.
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