Cyclooxygenase-1 and -2 Knockout Mice Demonstrate Increased Cardiac Ischemia/Reperfusion Injury but Are Protected by Acute Preconditioning | Zendy

Michael G.W. Camitta | Zendy; Scott A. Gabel | Zendy; Patricia C. Chulada | Zendy; J. Alyce Bradbury | Zendy; Robert Langenbach | Zendy; Darryl C. Zeldin | Zendy; Elizabeth W. Murphy | Zendy

Open Access

Cyclooxygenase-1 and -2 Knockout Mice Demonstrate Increased Cardiac Ischemia/Reperfusion Injury but Are Protected by Acute Preconditioning

Author(s) -

Michael G.W. Camitta,

Scott A. Gabel,

Patricia C. Chulada,

J. Alyce Bradbury,

Robert Langenbach,

Darryl C. Zeldin,

Elizabeth W. Murphy

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc4401.098429

Subject(s) - medicine , reperfusion injury , ischemia , ischemic preconditioning , cyclooxygenase , knockout mouse , myocardial reperfusion injury , pharmacology , anesthesia , cardiology , enzyme , receptor , biochemistry , chemistry

The purpose of this study was to examine the effects of cyclooxygenase (COX) deficiency on baseline functional characteristics and on recovery of left ventricular developed pressure (LVDP) after 20 minutes of global ischemia and 40 minutes of reperfusion in untreated and preconditioned hearts.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research