In Cardiomyocyte Hypoxia, Insulin-Like Growth Factor-I-Induced Antiapoptotic Signaling Requires Phosphatidylinositol-3-OH-Kinase-Dependent and Mitogen-Activated Protein Kinase-Dependent Activation of the Transcription Factor cAMP Response Element-Binding Protein | Zendy

Felix Mehrhof | Zendy; Frank Müller | Zendy; Martin Bergmann | Zendy; Peifeng Li | Zendy; Yibin Wang | Zendy; Wilhelm Schmitz | Zendy; Rainer Dietz | Zendy; Rüdiger von Harsdorf | Zendy

Open Access

In Cardiomyocyte Hypoxia, Insulin-Like Growth Factor-I-Induced Antiapoptotic Signaling Requires Phosphatidylinositol-3-OH-Kinase-Dependent and Mitogen-Activated Protein Kinase-Dependent Activation of the Transcription Factor cAMP Response Element-Binding Protein

Author(s) -

Felix Mehrhof,

Frank Müller,

Martin Bergmann,

Peifeng Li,

Yibin Wang,

Wilhelm Schmitz,

Rainer Dietz,

Rüdiger von Harsdorf

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc4201.097133

Subject(s) - creb , protein kinase b , pi3k/akt/mtor pathway , mapk/erk pathway , microbiology and biotechnology , protein kinase a , signal transduction , phosphorylation , kinase , transcription factor , activating transcription factor , biology , cancer research , biochemistry , unfolded protein response , gene , endoplasmic reticulum

A variety of pathologic stimuli lead to apoptosis of cardiomyocytes. Survival factors like insulin-like growth factor-I (IGF-I) exert anti-apoptotic effects in the heart. Yet the underlying signaling pathways are poorly understood.

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