Dysfunctional Endothelial Nitric Oxide Biosynthesis in Healthy Smokers With Impaired Endothelium-Dependent Vasodilatation | Zendy

Rajat S. Barua | Zendy; John A. Ambrose | Zendy; Lesley-Jane Eales-Reynolds | Zendy; Mary C. DeVoe | Zendy; John G. Zervas | Zendy; Dhajoy C. Saha | Zendy

Open Access

Dysfunctional Endothelial Nitric Oxide Biosynthesis in Healthy Smokers With Impaired Endothelium-Dependent Vasodilatation

Author(s) -

Rajat S. Barua,

John A. Ambrose,

Lesley-Jane Eales-Reynolds,

Mary C. DeVoe,

John G. Zervas,

Dhajoy C. Saha

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc4101.097525

Subject(s) - enos , medicine , basal (medicine) , umbilical vein , in vivo , vasodilation , endocrinology , endothelium , nitric oxide , endothelial dysfunction , in vitro , nitric oxide synthase , chemistry , biology , biochemistry , diabetes mellitus , microbiology and biotechnology

The mechanisms involved in the dysfunction of both endothelium-dependent vasodilatation (EDV) and NO biosynthesis related to smoking are unclear. In this study, EDV was assessed in healthy smokers and nonsmokers in vivo and, using serum from the same individuals, was related to the NO biosynthetic pathway in vitro.

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