Vascular Abnormalities and Elevated Blood Pressure in Mice Lacking Adrenomedullin Gene | Zendy

Takayuki Shindo | Zendy; Yukiko Kurihara | Zendy; Hiroaki Nishimatsu | Zendy; Nobuo Moriyama | Zendy; Masao Kakoki | Zendy; Yuhui Wang | Zendy; Yasushi Imai | Zendy; Aya Ebihara | Zendy; Tomoyuki Kuwaki | Zendy; Kihwan Ju | Zendy; Naoto Minamino | Zendy; Kenji Kangawa | Zendy; Takatoshi Ishikawa | Zendy; Minoru Fukuda | Zendy; Yoshihiro Akimoto | Zendy; Hayato Kawakami | Zendy; T. Imai | Zendy; Hiroyuki Morita | Zendy; Yoshio Yazaki | Zendy; Ryozo Nagai | Zendy; Yasunobu Hirata | Zendy; Hiroki Kurihara | Zendy

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Vascular Abnormalities and Elevated Blood Pressure in Mice Lacking Adrenomedullin Gene

Author(s) -

Takayuki Shindo,

Yukiko Kurihara,

Hiroaki Nishimatsu,

Nobuo Moriyama,

Masao Kakoki,

Yuhui Wang,

Yasushi Imai,

Aya Ebihara,

Tomoyuki Kuwaki,

Kihwan Ju,

Naoto Minamino,

Kenji Kangawa,

Takatoshi Ishikawa,

Minoru Fukuda,

Yoshihiro Akimoto,

Hayato Kawakami,

T. Imai,

Hiroyuki Morita,

Yoshio Yazaki,

Ryozo Nagai,

Yasunobu Hirata,

Hiroki Kurihara

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc4101.097111

Subject(s) - adrenomedullin , medicine , blood pressure , gene , cardiology , genetics , receptor , biology

Adrenomedullin (AM) is a vasodilating peptide involved in the regulation of circulatory homeostasis and in the pathophysiology of certain cardiovascular diseases. Levels of AM are markedly increased in the fetoplacental circulation during pregnancy, although its function there remains unknown. To clarify the physiological functions of AM, we chose a gene-targeting strategy in mice.

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