Adenovirus-Mediated Heme Oxygenase-1 Gene Transfer Inhibits the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice | Zendy

ShuHui Juan | Zendy; TzongShyuan Lee | Zendy; KuangWen Tseng | Zendy; JunYang Liou | Zendy; SongKun Shyue | Zendy; Kenneth K. Wu | Zendy; LeeYoung Chau | Zendy

Open Access

Adenovirus-Mediated Heme Oxygenase-1 Gene Transfer Inhibits the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice

Author(s) -

ShuHui Juan,

TzongShyuan Lee,

KuangWen Tseng,

JunYang Liou,

SongKun Shyue,

Kenneth K. Wu,

LeeYoung Chau

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc3801.095663

Subject(s) - hemin , heme oxygenase , transgene , medicine , genetic enhancement , apolipoprotein e , lesion , apolipoprotein b , adenoviridae , endothelium , genetically modified mouse , heme , in vivo , vascular smooth muscle , inflammation , endocrinology , pathology , biology , gene , cholesterol , biochemistry , disease , enzyme , microbiology and biotechnology , smooth muscle

Increasing evidence supports the role of heme oxygenase-1 (HO-1) in cytoprotective response and iron homeostasis. The object of this study was to investigate whether adenovirus-mediated gene transfer of HO-1 in arteries reduces iron overload and inhibits lesion formation in apolipoprotein E (apoE)-deficient mice.

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