Gap Junction Blockers Decrease Defibrillation Thresholds Without Changes in Ventricular Refractoriness in Isolated Rabbit Hearts | Zendy

Xiangqian Qi | Zendy; Pryamvada Varma | Zendy; David Newman | Zendy; Paul Dorian | Zendy

Open Access

Gap Junction Blockers Decrease Defibrillation Thresholds Without Changes in Ventricular Refractoriness in Isolated Rabbit Hearts

Author(s) -

Xiangqian Qi,

Pryamvada Varma,

David Newman,

Paul Dorian

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc3801.095587

Subject(s) - heptanol , lidocaine , defibrillation threshold , medicine , refractory period , electrophysiology , ventricular fibrillation , qrs complex , defibrillation , effective refractory period , sodium channel , anesthesia , cardiology , gap junction , repolarization , nerve conduction velocity , antiarrhythmic agent , sodium , chemistry , heart disease , biochemistry , intracellular , organic chemistry

The maintenance and termination of reentry arrhythmias are determined by tissue properties such as refractoriness and conduction velocity. Although the effects of Na(+) and K(+) channel block on electrophysiological properties and defibrillation threshold (DFT) have been studied, little is known about the effect of gap junction blockers on defibrillation and tissue electrophysiological properties.

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