Endothelium-Mediated Relaxation of Porcine Collateral-Dependent Arterioles Is Improved by Exercise Training
Author(s) -
Kawanza L. Griffin,
Christopher R. Woodman,
Elmer M. Price,
M. Harold Laughlin,
Janet L. Parker
Publication year - 2001
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/hc3601.094274
Subject(s) - medicine , cardiology , bradykinin , microcirculation , vasodilation , endothelium , arteriole , artery , collateral circulation , nitric oxide synthase , nitric oxide , receptor
Endothelium-dependent modulation of coronary tone is impaired in the collateral-dependent coronary microcirculation. We used a porcine model of chronic coronary occlusion and collateral development to evaluate the hypothesis that exercise training enhances endothelium-mediated relaxation and increases endothelial nitric oxide synthase (ecNOS) mRNA levels of collateral-dependent microvasculature.
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