Protection Against Autoimmune Myocarditis by Gene Transfer of Interleukin-10 by Electroporation | Zendy

Kenichi Watanabe | Zendy; Mikio Nakazawa | Zendy; Koichi Fuse | Zendy; Haruo Hanawa | Zendy; Makoto Kodama | Zendy; Yoshifusa Aizawa | Zendy; Toshio Ohnuki | Zendy; Fumitake Gejyo | Zendy; Hiroki Maruyama | Zendy; Junichi Miyazaki | Zendy

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Protection Against Autoimmune Myocarditis by Gene Transfer of Interleukin-10 by Electroporation

Author(s) -

Kenichi Watanabe,

Mikio Nakazawa,

Koichi Fuse,

Haruo Hanawa,

Makoto Kodama,

Yoshifusa Aizawa,

Toshio Ohnuki,

Fumitake Gejyo,

Hiroki Maruyama,

Junichi Miyazaki

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc3501.096190

Subject(s) - medicine , myocarditis , gene transfer , electroporation , immunology , interleukin , gene , cytokine , genetics , biology

Although immunosuppressive therapy for myocarditis has attracted a great deal of attention, its effectiveness is controversial. Interleukin (IL)-10 has a variety of immunomodulatory properties. Among the nonviral techniques for gene transfer in vivo, the direct injection of plasmid DNA into muscle is simple, inexpensive, and safe.

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