Open AccessAnti–Tumor Necrosis Factor-α Antibody Limits Heart Failure in a Transgenic Model
Author(s) -
Toshiaki Kadokami,
Carole B. Frye,
Bonnie Lemster,
Carrie Wagner,
Arthur M. Feldman,
Charles F. McTiernan
Publication year - 2001
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/hc3501.096063
Subject(s) - medicine , heart failure , tumor necrosis factor alpha , cardiac function curve , endocrinology , cardiology
- Tumor necrosis factor (TNF)-alpha has been implicated in the pathophysiology of congestive heart failure. A strain of transgenic mice (TNF1.6) with cardiac-specific overexpression of TNF-alpha develop congestive heart failure.
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