Folic Acid Prevents Nitroglycerin-Induced Nitric Oxide Synthase Dysfunction and Nitrate Tolerance | Zendy

Tommaso Gori | Zendy; Jason M Burstein | Zendy; Sofia B. Ahmed | Zendy; Steve Miner | Zendy; Abdul AlHesayen | Zendy; Susan Kelly | Zendy; John D. Parker | Zendy

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Folic Acid Prevents Nitroglycerin-Induced Nitric Oxide Synthase Dysfunction and Nitrate Tolerance

Author(s) -

Tommaso Gori,

Jason M Burstein,

Sofia B. Ahmed,

Steve Miner,

Abdul AlHesayen,

Susan Kelly,

John D. Parker

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc3501.095358

Subject(s) - medicine , tetrahydrobiopterin , nitric oxide synthase , nitric oxide , pharmacology , bioavailability , placebo , vasodilation , endothelial dysfunction , biopterin , transdermal , anesthesia , endocrinology , alternative medicine , pathology

In healthy humans, continuous treatment with nitroglycerin (GTN) causes nitric oxide synthase dysfunction, probably through the reduced bioavailability of tetrahydrobiopterin. Recent studies proposed that folic acid is involved in the regeneration of tetrahydrobiopterin in different disease states. Therefore, we investigated whether folic acid administration would prevent this phenomenon. We also sought to determine if folic acid supplementation could prevent the development of tolerance to GTN.

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