Activation of Signal Transducer and Activator of Transcription 3 Protects Cardiomyocytes from Hypoxia/Reoxygenation-Induced Oxidative Stress Through the Upregulation of Manganese Superoxide Dismutase | Zendy

Shinji Negoro | Zendy; Keita Kunisada | Zendy; Yasushi Fujio | Zendy; Masanobu Funamoto | Zendy; Martine I. Darville | Zendy; Décio L. Eizirik | Zendy; Tomoaki Osugi | Zendy; Masahiro Izumi | Zendy; Yuichi Oshima | Zendy; Yoshikazu Nakaoka | Zendy; Hisao Hirota | Zendy; Tadamitsu Kishimoto | Zendy; Keiko YamauchiTakihara | Zendy

Open Access

Activation of Signal Transducer and Activator of Transcription 3 Protects Cardiomyocytes from Hypoxia/Reoxygenation-Induced Oxidative Stress Through the Upregulation of Manganese Superoxide Dismutase

Author(s) -

Shinji Negoro,

Keita Kunisada,

Yasushi Fujio,

Masanobu Funamoto,

Martine I. Darville,

Décio L. Eizirik,

Tomoaki Osugi,

Masahiro Izumi,

Yuichi Oshima,

Yoshikazu Nakaoka,

Hisao Hirota,

Tadamitsu Kishimoto,

Keiko YamauchiTakihara

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc3401.095947

Subject(s) - reactive oxygen species , superoxide dismutase , stat3 , stat protein , oxidative stress , catalase , microbiology and biotechnology , glutathione peroxidase , activator (genetics) , lactate dehydrogenase , transfection , medicine , biology , signal transduction , biochemistry , enzyme , gene

Mice with cardiac-specific overexpression of signal transducer and activator of transcription 3 (STAT3) are resistant to doxorubicin-induced damage. The STAT3 signal may be involved in the detoxification of reactive oxygen species (ROS).

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