Density and Kinetics of I Kr and I Ks in Guinea Pig and Rabbit Ventricular Myocytes Explain Different Efficacy of I Ks Blockade at High Heart Rate in Guinea Pig and Rabbit | Zendy

Zhibo Lu | Zendy; Kaichiro Kamiya | Zendy; Tobias Opthof | Zendy; Kenji Yasui | Zendy; Itsuo Kodama | Zendy

Open Access

Density and Kinetics of I _Kr and I _Ks in Guinea Pig and Rabbit Ventricular Myocytes Explain Different Efficacy of I _Ks Blockade at High Heart Rate in Guinea Pig and Rabbit

Author(s) -

Zhibo Lu,

Kaichiro Kamiya,

Tobias Opthof,

Kenji Yasui,

Itsuo Kodama

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc3401.093151

Subject(s) - ventricle , guinea pig , blockade , myocyte , medicine , cardiology , bradycardia , heart rate , diastole , heart failure , receptor , blood pressure

Class III antiarrhythmic agents commonly exhibit reverse frequency-dependent prolongation of the action potential duration (APD). This is undesirable because of the danger of bradycardia-related arrhythmias and the limited protection against ventricular tachyarrhythmias. The effects of blockade of separate components of delayed rectifier K(+) current (I(K)) may help to develop agents effective at high heart rate.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research