Open AccessMacrophage Accumulation Associated With Rat Cardiac Allograft Rejection Detected by Magnetic Resonance Imaging With Ultrasmall Superparamagnetic Iron Oxide Particles
Author(s) -
Shinichi Kanno,
Yijen Wu,
Paul C. Lee,
Stephen Dodd,
Mangay Williams,
Bartley P. Griffith,
Chien Ho
Publication year - 2001
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/hc3401.093148
Subject(s) - medicine , transplantation , magnetic resonance imaging , heart transplantation , dextran , graft rejection , pathology , nuclear medicine , radiology , surgery , biochemistry , chemistry
Acute cardiac allograft rejection continues to be the cause of graft loss and contributes to the morbidity and mortality after cardiac transplantation. In this study, we report a new method for detecting organ rejection in transplantation with an MR-based technique using dextran-coated ultrasmall superparamagnetic iron oxide (USPIO) particles. These particles ( approximately 27 nm in diameter) are known to shorten relaxation times in MRI experiments.
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