Effects of Selective Cyclooxygenase-2 Inhibition on Vascular Responses and Thrombosis in Canine Coronary Arteries | Zendy

James K. Hennan | Zendy; Huang Jin | Zendy; Terrance D. Barrett | Zendy; Edward M. Driscoll | Zendy; David Willens | Zendy; Andrew M. Park | Zendy; Leslie J. Crofford | Zendy; Benedict R. Lucchesi | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Effects of Selective Cyclooxygenase-2 Inhibition on Vascular Responses and Thrombosis in Canine Coronary Arteries

Author(s) -

James K. Hennan,

Huang Jin,

Terrance D. Barrett,

Edward M. Driscoll,

David Willens,

Andrew M. Park,

Leslie J. Crofford,

Benedict R. Lucchesi

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc3301.092790

Subject(s) - medicine , prostacyclin , celecoxib , cyclooxygenase , arachidonic acid , vasodilation , aspirin , thrombosis , endothelium , pharmacology , endocrinology , biochemistry , enzyme , chemistry

Prostanoid synthesis via the action of cyclooxygenase-2 (COX-2) is a component of the inflammatory response. Prostacyclin, a product of COX-2 in vascular endothelium, has important physiological roles, such as increasing blood flow to injured tissues, reducing leukocyte adherence, and inhibiting platelet aggregation. We examined the possibility that selective COX-2 inhibition could suppress the protective effects of prostacyclin, resulting in an alteration of the hemostatic balance and vascular tone.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research