Altered Growth Responses of Pulmonary Artery Smooth Muscle Cells From Patients With Primary Pulmonary Hypertension to Transforming Growth Factor-β 1 and Bone Morphogenetic Proteins | Zendy

Nicholas W. Morrell | Zendy; Xudong Yang | Zendy; Paul D. Upton | Zendy; Karen B. Jourdan | Zendy; Neal Morgan | Zendy; Karen Sheares | Zendy; Richard C. Trembath | Zendy

Open Access

Altered Growth Responses of Pulmonary Artery Smooth Muscle Cells From Patients With Primary Pulmonary Hypertension to Transforming Growth Factor-β ₁ and Bone Morphogenetic Proteins

Author(s) -

Nicholas W. Morrell,

Xudong Yang,

Paul D. Upton,

Karen B. Jourdan,

Neal Morgan,

Karen Sheares,

Richard C. Trembath

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc3201.094152

Subject(s) - bmpr2 , bone morphogenetic protein receptor , bone morphogenetic protein , transforming growth factor , endocrinology , transforming growth factor beta , medicine , receptor , biology , microbiology and biotechnology , cancer research , gene , genetics

Mutations in the type II receptor for bone morphogenetic protein (BMPR-II), a receptor member of the transforming growth factor-beta (TGF-beta) superfamily, underlie many cases of familial and sporadic primary pulmonary hypertension (PPH). We postulated that pulmonary artery smooth muscle cells (PASMCs) from patients with PPH might demonstrate abnormal growth responses to TGF-beta superfamily members.

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