Upregulation of the Cardiac Monocarboxylate Transporter MCT1 in a Rat Model of Congestive Heart Failure | Zendy

Erlingur Jóhannsson | Zendy; Per Lunde | Zendy; Catherine Heddle | Zendy; Ivar Sjaastad | Zendy; Marion Thomas | Zendy; Linda Hildegard Bergersen | Zendy; Andrew P. Halestrap | Zendy; Theodor Blackstad | Zendy; Ole Petter Ottersen | Zendy; Ole M. Sejersted | Zendy

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Upregulation of the Cardiac Monocarboxylate Transporter MCT1 in a Rat Model of Congestive Heart Failure

Author(s) -

Erlingur Jóhannsson,

Per Lunde,

Catherine Heddle,

Ivar Sjaastad,

Marion Thomas,

Linda Hildegard Bergersen,

Andrew P. Halestrap,

Theodor Blackstad,

Ole Petter Ottersen,

Ole M. Sejersted

Publication year - 2001

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc3201.092286

Subject(s) - heart failure , medicine , downregulation and upregulation , transporter , cardiology , biochemistry , chemistry , gene

Cardiac metabolism becomes more dependent on carbohydrates in congestive heart failure (CHF), and lactate may be used as an important respiratory substrate. Monocarboxylate transporter 1 (MCT1) promotes cotransport of lactate and protons into and out of heart cells and conceivably flux of lactate between cells, because it is abundantly present in the intercalated disk.

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