Open AccessBiomechanical Strain Induces Class A Scavenger Receptor Expression in Human Monocyte/Macrophages and THP-1 Cells
Author(s) -
Hironosuke Sakamoto,
Masanori Aikawa,
Christopher C. Hill,
Daiana Weiss,
W. Robert Taylor,
Peter Libby,
Richard Lee
Publication year - 2001
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/hc2701.091070
Subject(s) - cd36 , scavenger receptor , monocyte , medicine , endocrinology , macrophage , receptor , foam cell , thp1 cell line , cholesterol , apolipoprotein b , receptor expression , lipoprotein , biology , cell culture , in vitro , biochemistry , genetics
Although hypertension is an important risk factor for the development of atherosclerosis, the mechanisms for this interaction are incompletely described. Previous studies have suggested that biomechanical strain regulates macrophage phenotype. We tested the hypothesis that biomechanical strain can induce expression of the class A scavenger receptor (SRA), an important lipoprotein receptor in atherogenesis.
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