Effect of Medroxyprogesterone Acetate on Vascular Inflammatory Markers in Postmenopausal Women Receiving Estrogen | Zendy

Akihiko Wakatsuki | Zendy; Yuji Okatani | Zendy; Nobuo Ikenoue | Zendy; Takao Fukaya | Zendy

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Effect of Medroxyprogesterone Acetate on Vascular Inflammatory Markers in Postmenopausal Women Receiving Estrogen

Author(s) -

Akihiko Wakatsuki,

Yuji Okatani,

Nobuo Ikenoue,

Takao Fukaya

Publication year - 2002

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc1202.105945

Subject(s) - estrogen , cell adhesion molecule , endocrinology , medroxyprogesterone acetate , proinflammatory cytokine , medicine , cell adhesion , adhesion , inflammation , chemistry , cell , biochemistry , immunology , organic chemistry

Estrogen increases C-reactive protein (CRP) in postmenopausal women. Estrogen also decreases cell adhesion molecules, whereas elevated CRP stimulates the expression of cell adhesion molecules. Because androgens have antiinflammatory effects, androgenic progestins such as medroxyprogesterone acetate (MPA) may inhibit proinflammatory effects of estrogen. We investigated the effects of MPA on estrogen-induced changes in acute inflammatory proteins and cell adhesion molecules in postmenopausal women.

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