Maternal Hypercholesterolemia During Pregnancy Promotes Early Atherogenesis in LDL Receptor-Deficient Mice and Alters Aortic Gene Expression Determined by Microarray | Zendy

Claudio Napoli | Zendy; Filomena de Nigris | Zendy; John S. Welch | Zendy; Federico Calara | Zendy; Robert O. Stuart | Zendy; Christopher K. Glass | Zendy; Wulf Palinski | Zendy

Open Access

Maternal Hypercholesterolemia During Pregnancy Promotes Early Atherogenesis in LDL Receptor-Deficient Mice and Alters Aortic Gene Expression Determined by Microarray

Author(s) -

Claudio Napoli,

Filomena de Nigris,

John S. Welch,

Federico Calara,

Robert O. Stuart,

Christopher K. Glass,

Wulf Palinski

Publication year - 2002

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc1102.106792

Subject(s) - offspring , fatty streak , fetus , microarray , endocrinology , medicine , gene expression , familial hypercholesterolemia , ldl receptor , microarray analysis techniques , pregnancy , gene , downregulation and upregulation , cholesterol , biology , andrology , lipoprotein , genetics

Maternal hypercholesterolemia during pregnancy is associated with markedly enhanced fatty streak formation in human fetal aortas and accelerated progression of atherosclerosis in normocholesterolemic children.

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