Open AccessBarium Reduces Resting Blood Flow and Inhibits Potassium-Induced Vasodilation in the Human Forearm
Author(s) -
Matthew Dawes,
Christine E. Sieniawska,
Trevor Delves,
Rahul Dwivedi,
Phil Chowienczyk,
James M. Ritter
Publication year - 2002
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/hc1102.105651
Subject(s) - ouabain , vasodilation , forearm , medicine , verapamil , endocrinology , vascular resistance , sodium nitroprusside , blood flow , potassium , brachial artery , plethysmograph , sodium , hemodynamics , chemistry , calcium , anatomy , blood pressure , nitric oxide , organic chemistry
Increasing extracellular K+ concentration within and just above the physiological range hyperpolarizes and relaxes vascular smooth muscle in vitro. These actions involve inwardly rectifying potassium channels (K(IR)) and Na+/K+ ATPase, which are inhibited, respectively, by Ba2+ and ouabain. The role (if any) of K(IR) in controlling human resistance vessel tone is unknown, and we investigated this in the forearm.
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