Functional and Biochemical Analysis of Endothelial (Dys)function and NO/cGMP Signaling in Human Blood Vessels With and Without Nitroglycerin Pretreatment | Zendy

Eberhard Schulz | Zendy; N. Tsilimingas | Zendy; Ruth Rinze | Zendy; B. Reiter | Zendy; Maria Wendt | Zendy; Mathias Oelze | Zendy; Silke Woelken-Weckmüller | Zendy; Ulrich Walter | Zendy; Hermann Reichenspurner | Zendy; Thomas Meinertz | Zendy; Thomas Münzel | Zendy

Open Access

Functional and Biochemical Analysis of Endothelial (Dys)function and NO/cGMP Signaling in Human Blood Vessels With and Without Nitroglycerin Pretreatment

Author(s) -

Eberhard Schulz,

N. Tsilimingas,

Ruth Rinze,

B. Reiter,

Maria Wendt,

Mathias Oelze,

Silke Woelken-Weckmüller,

Ulrich Walter,

Hermann Reichenspurner,

Thomas Meinertz,

Thomas Münzel

Publication year - 2002

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc1002.105186

Subject(s) - vasodilation , medicine , soluble guanylyl cyclase , endothelial dysfunction , endothelium , nitric oxide , pharmacology , acetylcholine , in vivo , phosphorylation , endocrinology , cyclic gmp , biochemistry , biology , microbiology and biotechnology

In experimental animal models, long-term in vivo treatment with nitroglycerin (NTG) induces both endothelial dysfunction and tolerance to nitrates. However, it is still controversial whether nitrate tolerance in humans is associated with both endothelial dysfunction and impaired vascular response to nitrovasodilator-derived NO.

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