Open AccessIntravenous Pulse Administration of Cyclophosphamide Is an Effective and Safe Treatment for Sensitized Cardiac Allograft Recipients
Author(s) -
Silviu Itescu,
Elizabeth Burke,
Katherine Lietz,
Ranjit John,
Donna Mancini,
Robert E. Michler,
Eric A. Rose,
Mehmet C. Öz,
Niloo M. Edwards
Publication year - 2002
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/hc1002.105128
Subject(s) - medicine , cyclophosphamide , immunosuppression , transplantation , gastroenterology , mycophenolic acid , sensitization , cumulative dose , immunology , chemotherapy
The proportion of cardiac transplant recipients with preexisting sensitization to HLA alloantigens has been increasing. Sensitization prolongs duration to obtaining a donor and predicts poorer long-term allograft survival because of increased risk of cellular rejections. We investigated the effect of cyclophosphamide pulse therapy in sensitized cardiac allograft recipients.
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