Fibrillin-1 Genotype Is Associated With Aortic Stiffness and Disease Severity in Patients With Coronary Artery Disease | Zendy

Tanya L. Medley | Zendy; Tim Cole | Zendy; Christoph D. Gatzka | Zendy; William Y.S. Wang | Zendy; Anthony M. Dart | Zendy; Bronwyn A. Kingwell | Zendy

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Fibrillin-1 Genotype Is Associated With Aortic Stiffness and Disease Severity in Patients With Coronary Artery Disease

Author(s) -

Tanya L. Medley,

Tim Cole,

Christoph D. Gatzka,

William Y.S. Wang,

Anthony M. Dart,

Bronwyn A. Kingwell

Publication year - 2002

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc0702.104129

Subject(s) - medicine , pulse pressure , cardiology , pulse wave velocity , genotype , blood pressure , population , coronary artery disease , fibrillin , arterial stiffness , marfan syndrome , genetics , environmental health , biology , gene

Elevated pulse pressure is associated strongly with adverse cardiovascular outcome; however, the genetic basis of this condition is unknown. This study examined whether genotypic variation in the extracellular matrix protein fibrillin-1, the Marfan gene, was associated with aortic stiffening and therefore could contribute to cardiovascular risk associated with pulse pressure elevation in coronary disease.

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