Open AccessAtrio-Sinus Interaction Demonstrated by Blockade of the Rapid Delayed Rectifier Current
Author(s) -
E. Etienne Verheijck,
Ronald Wilders,
Lennart N. Bouman
Publication year - 2002
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/hc0702.104128
Subject(s) - medicine , blockade , atrium (architecture) , herg , depolarization , cardiology , sinus (botany) , sinoatrial node , electrophysiology , atrial fibrillation , potassium channel , receptor , heart rate , biology , blood pressure , botany , genus
Proper pacemaking of the heart requires a specific organization of the sinoatrial (SA) node. The SA node drives the surrounding atrium but needs to be protected from its hyperpolarizing influence, which tends to suppress pacemaker activity. It has been suggested that the hyperpolarizing atrial influence is minimal at the site of the central nodal area.
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