Open AccessInsulin Causes Endothelial Dysfunction in Humans
Author(s) -
Guido Arcaro,
A Cretti,
Sara Balzano,
Alessandro Lechi,
Michele Muggeo,
Enzo Bonora,
Riccardo C. Bonadonna
Publication year - 2002
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/hc0502.103333
Subject(s) - hyperinsulinemia , medicine , endocrinology , endothelium , vasodilation , insulin , hyperinsulinism , endothelial dysfunction , glucose clamp technique , brachial artery , insulin resistance , pancreatic hormone , blood pressure
Insulin resistance is often accompanied by hyperinsulinemia and may predispose to atherosclerosis. Endothelium plays a central role in atherogenesis. The in vivo effects of hyperinsulinemia on endothelial function of large conduit arteries are unknown.
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