Activated Monocytes Induce Smooth Muscle Cell Death | Zendy

Puvi Seshiah | Zendy; Dean J. Kereiakes | Zendy; Sanjay S. Vasudevan | Zendy; Neuza Lopes | Zendy; Baogen Y. Su | Zendy; Nicholas A. Flavahan | Zendy; Pascal J. GoldschmidtClermont | Zendy

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Activated Monocytes Induce Smooth Muscle Cell Death

Author(s) -

Puvi Seshiah,

Dean J. Kereiakes,

Sanjay S. Vasudevan,

Neuza Lopes,

Baogen Y. Su,

Nicholas A. Flavahan,

Pascal J. GoldschmidtClermont

Publication year - 2002

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/hc0202.102248

Subject(s) - abciximab , medicine , vascular smooth muscle , apoptosis , eptifibatide , tirofiban , receptor , platelet , immunology , pharmacology , endocrinology , myocardial infarction , biology , biochemistry , smooth muscle , percutaneous coronary intervention , conventional pci

Plaque disruption is the inciting event for coronary thrombosis and acute coronary syndromes. Multiple factors influence plaque rupture, including the loss of vascular smooth muscle cells (VSMCs). We hypothesized that monocytes/macrophages (MMs) activated by macrophage colony-stimulating factor (M-CSF) are responsible for VSMC death.

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