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Atherosclerosis is a chronic inflammatory disease of the arterial wall, where it associates with oxidative stress and formation of oxidized lipids. The lipid oxidation product isoprostane iPF2alpha-III, also known as 8-isoPGF2alpha and 15-F2t-IsoP, is elevated in patients with cardiovascular disease and present in atherosclerotic lesions. Several proatherogenic biological effects have been attributed to this isoprostane, suggesting that it could be an active factor in the pathogenesis of the disease.

Involvement of Thromboxane Receptor in the Proatherogenic Effect of Isoprostane F 2α -III

Involvement of Thromboxane Receptor in the Proatherogenic Effect of Isoprostane F _2α -III