Involvement of Thromboxane Receptor in the Proatherogenic Effect of Isoprostane F 2α -III | Zendy

Myan Tang | Zendy; Tillmann Cyrus | Zendy; Yuemang Yao | Zendy; Luigina Vocun | Zendy; Domenico Praticò | Zendy

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Involvement of Thromboxane Receptor in the Proatherogenic Effect of Isoprostane F _2α -III

Author(s) -

Myan Tang,

Tillmann Cyrus,

Yuemang Yao,

Luigina Vocun,

Domenico Praticò

Publication year - 2005

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha105.562223

Subject(s) - isoprostane , medicine , oxidative stress , thromboxane receptor , endocrinology , thromboxane a2 , thromboxane , apolipoprotein b , pathogenesis , proinflammatory cytokine , apolipoprotein e , receptor , inflammation , platelet , lipid peroxidation , disease , cholesterol

Atherosclerosis is a chronic inflammatory disease of the arterial wall, where it associates with oxidative stress and formation of oxidized lipids. The lipid oxidation product isoprostane iPF2alpha-III, also known as 8-isoPGF2alpha and 15-F2t-IsoP, is elevated in patients with cardiovascular disease and present in atherosclerotic lesions. Several proatherogenic biological effects have been attributed to this isoprostane, suggesting that it could be an active factor in the pathogenesis of the disease.

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