Open AccessCardiovascular Safety of Degarelix Versus Leuprolide in Patients With Prostate Cancer: The Primary Results of the PRONOUNCE Randomized Trial
Author(s) -
Renato D. Lópes,
Celestia S. Higano,
Susan F. Slovin,
Adam J. Nelson,
Robert Bigelow,
Per Settergren Sørensen,
Chiara Melloni,
Shaun G. Goodman,
Christopher P. Evans,
Jan Nilsson,
Deepak L. Bhatt,
Noel W. Clarke,
Tine Kold Olesen,
Belinda T. Doyle-Olsen,
Henriette Kristensen,
Lauren Arney,
Matthew T. Roe,
John H. Alexander,
Mirjam Mol-Arts,
Samreen Mansor-Lefebvre,
Konstantin Zubovskiy,
Allan Blemings,
Klaus A. Dugi,
Gerald S. Bloomfield,
Chris Kontos,
Adam D. DeVore,
J. Dedrick Jordan,
Brad J. Kolls,
J. B. Matthews,
Rajendra H. Mehta,
Thomas J. Povsic,
Michael Morse,
Kenneth W. Mahaffey,
Susan Halabi,
Darryl P. Leong,
Laurence Klotz,
Neil Fleshner,
G. Kenneth Jansz,
Jonathan Giddens,
R. Blair Egerdie,
Joseph L. Chin,
Joseph Zadra,
Richard Casey,
Jean Simard,
Tamim Niazi,
AndréGuy Martin,
Marek Babjuk,
Jaroslav Hájek,
Jiří Klečka,
Jiří Kubeš,
Jan Schraml,
Jitka Jakesova,
J Vaňásek,
Bohuslav Melichar,
Heikki Seikkula,
M. Abdiche,
Marc Colombel,
P. Debourdeau,
G. Robert,
Arnauld Villers,
Guillaume Ploussard,
Benjamin Pradère,
F. Bruyère,
JeanLuc Descotes,
I. Ouzaïd,
Alexander Winter,
Herbert Hanitzsch,
H. Sperling,
Ralf Eckert,
Peter Hammerer,
E. Stagge,
F. Seseke,
Silvio Szymula,
Aristotelis Bamias,
A. Thanos,
Konstantinos Hatzimouratidis,
Charalambos Mamoulakis,
Haralabos P. Kalofonos,
Elżbieta Oszukowska,
Katarzyna Madziarska,
Jacek Fijuth,
Mateusz Obarzanowski,
B. Yа. Alekseev,
Vagif Atduev,
Pushkar' DIu,
Evgeniy Veliev,
A. V. Zyryаnov,
С Б Петров,
Evgeny Kopyltsov,
Vadim Kozlov,
Ladislav Macko,
J. Dúbravický,
Richard Polak,
Obaidullah Mir,
Marek Vargovcak,
I. Minčík,
J. Kliment,
Frederico Gonçalves,
J Mikuláš,
Roman Sokol,
Michal Korček,
Jozef Marko,
Viktor Kováčik,
Igor Milichovsky,
P. Dubinský,
J. Michael Lazarus,
Sanjay Dixit,
Euan Green,
Rajaguru Srinivasan,
Danish Mazhar,
Yeung Ng,
Naveed Sarwar,
Craig Herman,
Frederick Snoy,
Robert Given,
Ronald Suh,
David Lipsitz,
James L. Bailen,
Lawrence Gervasi,
Idalia Acosta,
Laurence Belkoff,
Ning Wu,
Jeffrey A. Frankel,
Lawrence I. Karsh,
Bryant Poole,
David Lieber,
Jason Engel,
Mohamed Bidair,
Steven Rosenberg,
Paul Sieber,
Adam Perzin,
Susan Kalota,
Amar Singh,
Ralph A. Henderson,
Jeffrey D. Wayne,
Moben Mirza,
Richard D’Anna,
Fredrick Wolk,
Osvaldo Padron,
Kathryn Bylow,
Jonathan Rubenstein,
Benjamin A. Gartrell,
Michael Schwartz,
Kalpesh Patel,
Ajit Maniam,
Thomas E. Keane,
Michael Goodman,
Charles Bane,
Michael Jae-Yoon Chung,
Stephen J. Savage,
Edward Uchio,
Minh Son Nguyen,
William J. Aronson,
Rakesh Khanna,
Carlton Barnswell
Publication year - 2021
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.121.056810
Subject(s) - medicine , prostate cancer , adverse effect , myocardial infarction , randomized controlled trial , hazard ratio , cancer , concomitant , urology , confidence interval
The relative cardiovascular safety of gonadotropin-releasing hormone (GnRH) antagonists compared with GnRH agonists in men with prostate cancer and known atherosclerotic cardiovascular disease remains controversial.
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