One-Year Committed Exercise Training Reverses Abnormal Left Ventricular Myocardial Stiffness in Patients With Stage B Heart Failure With Preserved Ejection Fraction | Zendy

Michinari Hieda | Zendy; Satyam Sarma | Zendy; Christopher M. Hearon | Zendy; James P. MacNamara | Zendy; Katrin A. Dias | Zendy; Mitchel Samels | Zendy; Dean Palmer | Zendy; Sheryl Livingston | Zendy; Margot Morris | Zendy; Benjamin D. Levine | Zendy

Open Access

One-Year Committed Exercise Training Reverses Abnormal Left Ventricular Myocardial Stiffness in Patients With Stage B Heart Failure With Preserved Ejection Fraction

Author(s) -

Michinari Hieda,

Satyam Sarma,

Christopher M. Hearon,

James P. MacNamara,

Katrin A. Dias,

Mitchel Samels,

Dean Palmer,

Sheryl Livingston,

Margot Morris,

Benjamin D. Levine

Publication year - 2021

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.121.054117

Subject(s) - medicine , ejection fraction , cardiology , heart failure , stage (stratigraphy) , paleontology , biology

Individuals with left ventricular (LV) hypertrophy and elevated cardiac biomarkers in middle age are at increased risk for the development of heart failure with preserved ejection fraction. Prolonged exercise training reverses the LV stiffening associated with healthy but sedentary aging; however, whether it can also normalize LV myocardial stiffness in patients at high risk for heart failure with preserved ejection fraction is unknown. In a prospective, randomized controlled trial, we hypothesized that 1-year prolonged exercise training would reduce LV myocardial stiffness in patients with LV hypertrophy.

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