Progress Toward Cardiac Xenotransplantation | Zendy

Richard N. Pierson | Zendy; Jay A. Fishman | Zendy; Gregory D. Lewis | Zendy; David A. D’Alessandro | Zendy; Margaret R. Connolly | Zendy; Lars Burdorf | Zendy; Joren C. Madsen | Zendy; Agnes M. Azimzadeh | Zendy

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Progress Toward Cardiac Xenotransplantation

Author(s) -

Richard N. Pierson,

Jay A. Fishman,

Gregory D. Lewis,

David A. D’Alessandro,

Margaret R. Connolly,

Lars Burdorf,

Joren C. Madsen,

Agnes M. Azimzadeh

Publication year - 2020

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.120.048186

Subject(s) - xenotransplantation , medicine , translation (biology) , heart failure , intensive care medicine , transplantation , pharmacology , biology , genetics , messenger rna , gene

Consistent survival of life-supporting pig heart xenograft recipients beyond 90 days was recently reported using genetically modified pigs and a clinically applicable drug treatment regimen. If this remarkable achievement proves reproducible, published benchmarks for clinical translation of cardiac xenografts appear to be within reach. Key mechanistic insights are summarized here that informed recent pig design and therapeutic choices, which together appear likely to enable early clinical translation.

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