Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis
Author(s) -
Sejin Jeon,
Tae Kyeong Kim,
SeJin Jeong,
InHyuk Jung,
Nayoung Kim,
Mi-Ni Lee,
Seong-Keun Sonn,
Seungwoon Seo,
Jing Jin,
Hyae Yon Kweon,
Sinai Kim,
Dahee Shim,
Young Mi Park,
SangHak Lee,
Kyu-Won Kim,
Myron I. Cybulsky,
Hyunbo Shim,
TaeYoung Roh,
WoongYang Park,
HaeOck Lee,
JaeHoon Choi,
Sung Ho Park,
Goo Taeg Oh
Publication year - 2020
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.120.046907
Subject(s) - medicine , inflammation , pharmacology , immunology
Macrophages produce many inflammation-associated molecules, released by matrix metalloproteinases, such as adhesion molecules, and cytokines, as well, which play a crucial role in atherosclerosis. In this context, we investigated the relationship between Ninjurin-1 (Ninj1 [nerve injury-induced protein]), a novel matrix metalloproteinase 9 substrate, expression, and atherosclerosis progression.
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