Prospective Multicenter Study of Myocardial Recovery Using Left Ventricular Assist Devices (RESTAGE-HF [Remission from Stage D Heart Failure]) | Zendy

Emma J. Birks | Zendy; Stavros G. Drakos | Zendy; Snehal R. Patel | Zendy; Brian D. Lowes | Zendy; Craig H. Selzman | Zendy; Randall C. Starling | Zendy; Jaimin R. Trivedi | Zendy; Mark S. Slaughter | Zendy; P. Alturi | Zendy; Daniel J. Goldstein | Zendy; Simon Maybaum | Zendy; John Um | Zendy; Kenneth B. Margulies | Zendy; Josef Stehlik | Zendy; Chris Cunningham | Zendy; David J. Farrar | Zendy; J. Eduardo Rame | Zendy

Open Access

Prospective Multicenter Study of Myocardial Recovery Using Left Ventricular Assist Devices (RESTAGE-HF [Remission from Stage D Heart Failure])

Author(s) -

Emma J. Birks,

Stavros G. Drakos,

Snehal R. Patel,

Brian D. Lowes,

Craig H. Selzman,

Randall C. Starling,

Jaimin R. Trivedi,

Mark S. Slaughter,

P. Alturi,

Daniel J. Goldstein,

Simon Maybaum,

John Um,

Kenneth B. Margulies,

Josef Stehlik,

Chris Cunningham,

David J. Farrar,

J. Eduardo Rame

Publication year - 2020

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.120.046415

Subject(s) - medicine , heart failure , cardiology , ejection fraction , ventricular assist device , pulmonary wedge pressure , inotrope , cardiomyopathy , clinical endpoint , ischemic cardiomyopathy , heart transplantation , prospective cohort study , randomized controlled trial

Left ventricular assist device (LVAD) unloading and hemodynamic support in patients with advanced chronic heart failure can result in significant improvement in cardiac function allowing LVAD removal; however, the rate of this is generally considered to be low. This prospective multicenter nonrandomized study (RESTAGE-HF [Remission from Stage D Heart Failure]) investigated whether a protocol of optimized LVAD mechanical unloading, combined with standardized specific pharmacological therapy to induce reverse remodeling and regular testing of underlying myocardial function, could produce a higher incidence of LVAD explantation.

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