Empagliflozin in Heart Failure | Zendy

Matthew D. Griffin | Zendy; Veena S. Rao | Zendy; Juan B. IveyMiranda | Zendy; James H. Fleming | Zendy; Devin Mahoney | Zendy; Christopher Maulion | Zendy; Nisha Suda | Zendy; Krishmita Siwakoti | Zendy; Tariq Ahmad | Zendy; Daniel Jacoby | Zendy; Ralph Riello | Zendy; Lavanya Bellumkonda | Zendy; Zachary L. Cox | Zendy; Sean P. Collins | Zendy; Sangchoon Jeon | Zendy; Jeffrey M. Turner | Zendy; F. Perry Wilson | Zendy; Javed Butler | Zendy; Silvio E. Inzucchi | Zendy; Jeffrey M. Testani | Zendy

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Empagliflozin in Heart Failure

Author(s) -

Matthew D. Griffin,

Veena S. Rao,

Juan B. IveyMiranda,

James H. Fleming,

Devin Mahoney,

Christopher Maulion,

Nisha Suda,

Krishmita Siwakoti,

Tariq Ahmad,

Daniel Jacoby,

Ralph Riello,

Lavanya Bellumkonda,

Zachary L. Cox,

Sean P. Collins,

Sangchoon Jeon,

Jeffrey M. Turner,

F. Perry Wilson,

Javed Butler,

Silvio E. Inzucchi,

Jeffrey M. Testani

Publication year - 2020

Publication title -

circulation

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.120.045691

Subject(s) - empagliflozin , medicine , heart failure , diuretic , furosemide , cotransporter , benzhydryl compounds , pharmacology , intravascular volume status , sodium , cardiology , diabetes mellitus , intensive care medicine , endocrinology , type 2 diabetes , hemodynamics , chemistry , organic chemistry , bisphenol a , epoxy

Sodium-glucose cotransporter-2 inhibitors improve heart failure-related outcomes. The mechanisms underlying these benefits are not well understood, but diuretic properties may contribute. Traditional diuretics such as furosemide induce substantial neurohormonal activation, contributing to the limited improvement in intravascular volume often seen with these agents. However, the proximal tubular site of action of the sodium-glucose cotransporter-2 inhibitors may help circumvent these limitations.

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