Cyclodextrin Prevents Abdominal Aortic Aneurysm via Activation of Vascular Smooth Muscle Cell Transcription Factor EB | Zendy

Haocheng Lu | Zendy; Jinjian Sun | Zendy; Wenying Liang | Zendy; Ziyi Chang | Zendy; Oren Rom | Zendy; Yang Zhao | Zendy; Guizhen Zhao | Zendy; Wenhao Xiong | Zendy; Huilun Wang | Zendy; Tianqing Zhu | Zendy; Yanhong Guo | Zendy; Lin Chang | Zendy; Minerva T. Garcia-Barrio | Zendy; Jifeng Zhang | Zendy; Y. Eugene Chen | Zendy; Yanbo Fan | Zendy

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Cyclodextrin Prevents Abdominal Aortic Aneurysm via Activation of Vascular Smooth Muscle Cell Transcription Factor EB

Author(s) -

Haocheng Lu,

Jinjian Sun,

Wenying Liang,

Ziyi Chang,

Oren Rom,

Yang Zhao,

Guizhen Zhao,

Wenhao Xiong,

Huilun Wang,

Tianqing Zhu,

Yanhong Guo,

Lin Chang,

Minerva T. Garcia-Barrio,

Jifeng Zhang,

Y. Eugene Chen,

Yanbo Fan

Publication year - 2020

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.119.044803

Subject(s) - tfeb , vascular smooth muscle , cancer research , microbiology and biotechnology , autophagy , transcription factor , apoptosis , medicine , biology , endocrinology , biochemistry , gene , smooth muscle

Abdominal aortic aneurysm (AAA) is a severe aortic disease with a high mortality rate in the event of rupture. Pharmacological therapy is needed to inhibit AAA expansion and prevent aneurysm rupture. Transcription factor EB (TFEB), a master regulator of autophagy and lysosome biogenesis, is critical to maintain cell homeostasis. In this study, we aim to investigate the role of vascular smooth muscle cell (VSMC) TFEB in the development of AAA and establish TFEB as a novel target to treat AAA.

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