Effect of Dapagliflozin on Atrial Fibrillation in Patients With Type 2 Diabetes Mellitus | Zendy

Thomas A. Zelniker | Zendy; Marc P. Bonaca | Zendy; Remo H.M. Furtado | Zendy; Ofri Mosenzon | Zendy; Julia Kuder | Zendy; Sabina A. Murphy | Zendy; Deepak L. Bhatt | Zendy; Lawrence A. Leiter | Zendy; Darren K. McGuire | Zendy; John Wilding | Zendy; Andrzej Budaj | Zendy; Róbert Gábor Kiss | Zendy; Francisco Padilla | Zendy; Ingrid GauseNilsson | Zendy; Anna Maria Langkilde | Zendy; Itamar Raz | Zendy; Marc S. Sabatine | Zendy; Stephen D. Wiviott | Zendy

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Effect of Dapagliflozin on Atrial Fibrillation in Patients With Type 2 Diabetes Mellitus

Author(s) -

Thomas A. Zelniker,

Marc P. Bonaca,

Remo H.M. Furtado,

Ofri Mosenzon,

Julia Kuder,

Sabina A. Murphy,

Deepak L. Bhatt,

Lawrence A. Leiter,

Darren K. McGuire,

John Wilding,

Andrzej Budaj,

Róbert Gábor Kiss,

Francisco Padilla,

Ingrid GauseNilsson,

Anna Maria Langkilde,

Itamar Raz,

Marc S. Sabatine,

Stephen D. Wiviott

Publication year - 2020

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.119.044183

Subject(s) - dapagliflozin , medicine , atrial fibrillation , cardiology , type 2 diabetes mellitus , diabetes mellitus , myocardial infarction , heart failure , hazard ratio , type 2 diabetes , atrial flutter , endocrinology , confidence interval

Atrial fibrillation (AF) and atrial flutter (AFL) are associated with both diabetes mellitus and its related comorbidities, including hypertension, obesity, and heart failure (HF). SGLT2 (sodium-glucose cotransporter 2) inhibitors have been shown to lower blood pressure, reduce weight, have salutary effects on left ventricular remodeling, and reduce hospitalization for HF and cardiovascular death in patients with type 2 diabetes mellitus. We therefore investigated whether SGLT2 inhibitors could also reduce the risk of AF/AFL.

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