Open AccessEndothelial Cell–Derived Interleukin-18 Released During Ischemia Reperfusion Injury Selectively Expands T Peripheral Helper Cells to Promote Alloantibody Production
Author(s) -
Lufang Liu,
Caodi Fang,
Whitney Fu,
Bo Jiang,
Guangxin Li,
Lingfeng Qin,
Jacob Rosenbluth,
Gavin Gong,
Catherine Xie,
Peter S. Yoo,
George Tellides,
Jordan S. Pober,
Dan Janewit
Publication year - 2019
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.119.042501
Subject(s) - medicine , ischemia , reperfusion injury , immunology , peripheral , endothelial stem cell , interleukin , cytokine , in vitro , biochemistry , chemistry
Ischemia reperfusion injury (IRI) predisposes to the formation of donor-specific antibodies, a factor contributing to chronic rejection and late allograft loss.
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