Omega-3 Polyunsaturated Fatty Acids Decrease Aortic Valve Disease Through the Resolvin E1 and ChemR23 Axis | Zendy

Gonzalo Artiach | Zendy; Miguel Carracedo | Zendy; Oscar Plunde | Zendy; Craig E. Wheelock | Zendy; Silke Thul | Zendy; Peter Sjövall | Zendy; Anders FrancoCereceda | Zendy; Andrés LagunaFernandez | Zendy; Hildur Arnardottir | Zendy; Magnus Bäck | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Omega-3 Polyunsaturated Fatty Acids Decrease Aortic Valve Disease Through the Resolvin E1 and ChemR23 Axis

Author(s) -

Gonzalo Artiach,

Miguel Carracedo,

Oscar Plunde,

Craig E. Wheelock,

Silke Thul,

Peter Sjövall,

Anders FrancoCereceda,

Andrés LagunaFernandez,

Hildur Arnardottir,

Magnus Bäck

Publication year - 2020

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.119.041868

Subject(s) - polyunsaturated fatty acid , calcification , aortic valve , medicine , aortic valve stenosis , lipid signaling , endocrinology , cardiology , inflammation , biology , biochemistry , fatty acid

Aortic valve stenosis (AVS), which is the most common valvular heart disease, causes a progressive narrowing of the aortic valve as a consequence of thickening and calcification of the aortic valve leaflets. The beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) in cardiovascular prevention have recently been demonstrated in a large randomized, controlled trial. In addition, n-3 PUFAs serve as the substrate for the synthesis of specialized proresolving mediators, which are known by their potent beneficial anti-inflammatory, proresolving, and tissue-modifying properties in cardiovascular disease. However, the effects of n-3 PUFA and specialized proresolving mediators on AVS have not yet been determined. The aim of this study was to identify the role of n-3 PUFA-derived specialized proresolving mediators in relation to the development of AVS.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research