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Dysfunctional High-Density Lipoproteins Are Associated With a Greater Incidence of Acute Coronary Syndrome in a Population at High Cardiovascular Risk
Author(s) -
María Trinidad Soria-Florido,
Olga Castañer,
Camille Lassale,
Ramón Estruch,
Jordi SalasSalvadó,
Miguel Ángel MartínezGonzález,
Dolores Corella,
Emilio Ros,
Fernando Arós,
Roberto Elosúa,
José Lapetra,
Miquel Fiol,
Ángel M. AlonsoGómez,
Enrique GómezGracia,
Lluís SerraMajem,
Xavier Pintó,
Mònica Bulló,
Miguel RuizCanela,
José V. Sorlí,
Álvaro Hernáez,
Montserrat Fitó
Publication year - 2020
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.119.041658
Subject(s) - medicine , cholesterol , apolipoprotein b , acute coronary syndrome , odds ratio , myocardial infarction , endocrinology , high density lipoprotein , population , body mass index , unstable angina , cardiology , environmental health
Studies have failed to establish a clear link between high-density lipoprotein (HDL) cholesterol and cardiovascular disease, leading to the hypothesis that the atheroprotective role of HDL lies in its biological activity rather than in its cholesterol content. However, to date, the association between HDL functional characteristics and acute coronary syndrome has not been investigated comprehensively.

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