Phospholemman Phosphorylation Regulates Vascular Tone, Blood Pressure, and Hypertension in Mice and Humans | Zendy

Andrii Boguslavskyi | Zendy; Sergiy Tokar | Zendy; Oleksandra Prysyazhna | Zendy; Olena Rudyk | Zendy; David Sánchez-Tatay | Zendy; Hamish A.L. Lemmey | Zendy; Kim A. Dora | Zendy; C J Garland | Zendy; Helen R. Warren | Zendy; Alex S. F. Doney | Zendy; Nicholette D. Palmer | Zendy; Mark J. Caulfield | Zendy; Julia M. Vlachaki Walker | Zendy; J. W. Howie | Zendy; William Fuller | Zendy; Michael J. Shattock | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Phospholemman Phosphorylation Regulates Vascular Tone, Blood Pressure, and Hypertension in Mice and Humans

Author(s) -

Andrii Boguslavskyi,

Sergiy Tokar,

Oleksandra Prysyazhna,

Olena Rudyk,

David Sánchez-Tatay,

Hamish A.L. Lemmey,

Kim A. Dora,

C J Garland,

Helen R. Warren,

Alex S. F. Doney,

Nicholette D. Palmer,

Mark J. Caulfield,

Julia M. Vlachaki Walker,

J. W. Howie,

William Fuller,

Michael J. Shattock

Publication year - 2020

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.119.040557

Subject(s) - phosphorylation , medicine , dephosphorylation , microbiology and biotechnology , endocrinology , biology , phosphatase

Although it has long been recognized that smooth muscle Na/K ATPase modulates vascular tone and blood pressure (BP), the role of its accessory protein phospholemman has not been characterized. The aim of this study was to test the hypothesis that phospholemman phosphorylation regulates vascular tone in vitro and that this mechanism plays an important role in modulation of vascular function and BP in experimental models in vivo and in humans.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research