Six-Month Results of Treatment-Blinded Medication Titration for Hypertension Control After Randomization to Endovascular Ultrasound Renal Denervation or a Sham Procedure in the RADIANCE-HTN SOLO Trial | Zendy

Michel Azizi | Zendy; Roland E. Schmieder | Zendy; Felix Mahfoud | Zendy; Michael A. Weber | Zendy; Joost Daemen | Zendy; Melvin D. Lobo | Zendy; Andrew S.P. Sharp | Zendy; Michael J. Bloch | Zendy; Jan Basile | Zendy; Yale Wang | Zendy; Manish Saxena | Zendy; Philipp Lurz | Zendy; Florian Rader | Zendy; Jeremy Sayer | Zendy; Naomi D.L. Fisher | Zendy; David Fouassier | Zendy; Neil C. Barman | Zendy; Helen Reeve-Stoffer | Zendy; Candace K. McClure | Zendy; Ajay J. Kirtane | Zendy; Desmond Jay | Zendy; Nedaa Skeik | Zendy; Robert S. Schwartz | Zendy; Suhail Dohad | Zendy; Ronald G. Victor | Zendy; Kintur Sanghvi | Zendy; Josh Costello | Zendy; Courtney Walsh | Zendy; Josephine Abraham | Zendy; Theophilus Owan | Zendy; Anu Abraham | Zendy; Laura Mauri | Zendy; Piotr Sobieszczky | Zendy; Jonathan S. Williams | Zendy; Chanwit Roongsritong | Zendy; Thomas M. Todoran | Zendy; Eric R. Powers | Zendy; Emily Hodskins | Zendy; Pete Fong | Zendy; Cheryl L. Laffer | Zendy; James S. Gainer | Zendy; Mark Robbins | Zendy; John P. Reilly | Zendy; Michael Cash | Zendy; Jessie Goldman | Zendy; Sandeep Aggarwal | Zendy; Gary S. Ledley | Zendy; David His | Zendy; Scott D. Martin | Zendy; Edward L. Portnay | Zendy; David A. Calhoun | Zendy; Thomas McElderry | Zendy; William Maddox | Zendy; Suzanne Oparil | Zendy; Pei-Hsiu Huang | Zendy; Powell Jose | Zendy; Matheen Khuddus | Zendy; Suzanne Zentko | Zendy; James O’Meara | Zendy; Ilie Barb | Zendy; Joseph Garasic | Zendy; Doug Drachman | Zendy; Randy Zusman | Zendy; Kenneth Rosenfield | Zendy; Chandan Devireddy | Zendy; Janice P. Lea | Zendy; Bryan Wells | Zendy; Rick Stouffer | Zendy; Alan L. Hinderliter | Zendy; Eric Pauley | Zendy; Srinivasa Potluri | Zendy; Scott Biedermann | Zendy; Sripal Bangalore | Zendy; Stephen Williams | Zendy; David Zidar | Zendy; Mehdi H. Shishehbor | Zendy; Barry Effron | Zendy; Marco Costa | Zendy; Jai Radhakrishnan | Zendy; Anthony Mathur | Zendy; Ajay Jain | Zendy; Sudha Ganesh Iyer | Zendy; Nicholas Robinson | Zendy; Sadat Ali Edroos | Zendy; Terry Levy | Zendy; Amit Patel | Zendy; David Beckett | Zendy; Clare Bent | Zendy; Justin E. Davies | Zendy; Neil Chapman | Zendy; Matthew Shun Shin | Zendy; James P. Howard | Zendy; Anil Joseph | Zendy; Richard D’Souza | Zendy; Robert Gerber | Zendy; Mohamad Faris | Zendy; Andrew John Marshall | Zendy; Cristina Elorz | Zendy; Robert Höllriegel | Zendy; Karl Fengler | Zendy; Karl-Philipp Rommel | Zendy; Michael Böhm | Zendy; Sebastian Ewen | Zendy; Jelena Lučić | Zendy; Christian Ott | Zendy; Axel Schmid | Zendy; Michael Uder | Zendy; Christian Rump | Zendy; Johannes Stegbauer | Zendy; Patric Kröpil | Zendy; Marc Sapoval | Zendy; Erika Cornu | Zendy; Aurélien Lorthioir | Zendy; Philippe Gosse | Zendy; Antoine Crémer | Zendy; H. Trillaud | Zendy; Panteleimon Papadopoulos | Zendy; Atul Pathak | Zendy; Benjamin Honton | Zendy; Pierre Lantelme | Zendy; Constance Berge | Zendy; PierreYves Courand | Zendy; Lida Feyz | Zendy; Peter J. Blankestijn | Zendy; Michiel Voskuil | Zendy; Zwaantina Rittersma | Zendy; Abraham A. Kroon | Zendy; Wim H. van Zwam | Zendy; Alexandre Persu | Zendy; Jean Renkin | Zendy

Open Access

Six-Month Results of Treatment-Blinded Medication Titration for Hypertension Control After Randomization to Endovascular Ultrasound Renal Denervation or a Sham Procedure in the RADIANCE-HTN SOLO Trial

Author(s) -

Michel Azizi,

Roland E. Schmieder,

Felix Mahfoud,

Michael A. Weber,

Joost Daemen,

Melvin D. Lobo,

Andrew S.P. Sharp,

Michael J. Bloch,

Jan Basile,

Yale Wang,

Manish Saxena,

Philipp Lurz,

Florian Rader,

Jeremy Sayer,

Naomi D.L. Fisher,

David Fouassier,

Neil C. Barman,

Helen Reeve-Stoffer,

Candace K. McClure,

Ajay J. Kirtane,

Desmond Jay,

Nedaa Skeik,

Robert S. Schwartz,

Suhail Dohad,

Ronald G. Victor,

Kintur Sanghvi,

Josh Costello,

Courtney Walsh,

Josephine Abraham,

Theophilus Owan,

Anu Abraham,

Laura Mauri,

Piotr Sobieszczky,

Jonathan S. Williams,

Chanwit Roongsritong,

Thomas M. Todoran,

Eric R. Powers,

Emily Hodskins,

Pete Fong,

Cheryl L. Laffer,

James S. Gainer,

Mark Robbins,

John P. Reilly,

Michael Cash,

Jessie Goldman,

Sandeep Aggarwal,

Gary S. Ledley,

David His,

Scott D. Martin,

Edward L. Portnay,

David A. Calhoun,

Thomas McElderry,

William Maddox,

Suzanne Oparil,

Pei-Hsiu Huang,

Powell Jose,

Matheen Khuddus,

Suzanne Zentko,

James O’Meara,

Ilie Barb,

Joseph Garasic,

Doug Drachman,

Randy Zusman,

Kenneth Rosenfield,

Chandan Devireddy,

Janice P. Lea,

Bryan Wells,

Rick Stouffer,

Alan L. Hinderliter,

Eric Pauley,

Srinivasa Potluri,

Scott Biedermann,

Sripal Bangalore,

Stephen Williams,

David Zidar,

Mehdi H. Shishehbor,

Barry Effron,

Marco Costa,

Jai Radhakrishnan,

Anthony Mathur,

Ajay Jain,

Sudha Ganesh Iyer,

Nicholas Robinson,

Sadat Ali Edroos,

Terry Levy,

Amit Patel,

David Beckett,

Clare Bent,

Justin E. Davies,

Neil Chapman,

Matthew Shun Shin,

James P. Howard,

Anil Joseph,

Richard D’Souza,

Robert Gerber,

Mohamad Faris,

Andrew John Marshall,

Cristina Elorz,

Robert Höllriegel,

Karl Fengler,

Karl-Philipp Rommel,

Michael Böhm,

Sebastian Ewen,

Jelena Lučić,

Christian Ott,

Axel Schmid,

Michael Uder,

Christian Rump,

Johannes Stegbauer,

Patric Kröpil,

Marc Sapoval,

Erika Cornu,

Aurélien Lorthioir,

Philippe Gosse,

Antoine Crémer,

H. Trillaud,

Panteleimon Papadopoulos,

Atul Pathak,

Benjamin Honton,

Pierre Lantelme,

Constance Berge,

PierreYves Courand,

Lida Feyz,

Peter J. Blankestijn,

Michiel Voskuil,

Zwaantina Rittersma,

Abraham A. Kroon,

Wim H. van Zwam,

Alexandre Persu,

Jean Renkin

Publication year - 2019

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.119.040451

Subject(s) - medicine , hydrochlorothiazide , blood pressure , amlodipine , ambulatory blood pressure , randomization , ambulatory , randomized controlled trial , diuretic , discontinuation , anesthesia

The multicenter, international, randomized, blinded, sham-controlled RADIANCE-HTN SOLO trial (A Study of the ReCor Medical Paradise System in Clinical Hypertension) demonstrated a 6.3 mm Hg greater reduction in daytime ambulatory systolic blood pressure (BP) at 2 months by endovascular ultrasound renal denervation (RDN) compared with a sham procedure among patients not treated with antihypertensive medications. We report 6-month results after the addition of a recommended standardized stepped-care antihypertensive treatment to the randomized endovascular procedure under continued blinding to initial treatment.

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