Increased Myocardial Stiffness in Patients With High-Risk Left Ventricular Hypertrophy | Zendy

Michinari Hieda | Zendy; Satyam Sarma | Zendy; Christopher M. Hearon | Zendy; Katrin A. Dias | Zendy; Jose Martinez | Zendy; Mitchel Samels | Zendy; Braden Everding | Zendy; Dean Palmer | Zendy; Sheryl Livingston | Zendy; Margot Morris | Zendy; Erin J. Howden | Zendy; Benjamin D. Levine | Zendy

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Increased Myocardial Stiffness in Patients With High-Risk Left Ventricular Hypertrophy

Author(s) -

Michinari Hieda,

Satyam Sarma,

Christopher M. Hearon,

Katrin A. Dias,

Jose Martinez,

Mitchel Samels,

Braden Everding,

Dean Palmer,

Sheryl Livingston,

Margot Morris,

Erin J. Howden,

Benjamin D. Levine

Publication year - 2019

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.119.040332

Subject(s) - medicine , cardiology , preload , pulmonary wedge pressure , heart failure , ejection fraction , left ventricular hypertrophy , heart failure with preserved ejection fraction , blood pressure , pulmonary hypertension , hemodynamics

Individuals with left ventricular hypertrophy (LVH) and elevated cardiac biomarkers in middle age are at high risk for the development of heart failure with preserved ejection fraction (HFpEF). However, it is unknown what the pathophysiological underpinnings of this high-risk state may be. We tested the hypothesis that patients with LVH and elevated cardiac biomarkers would demonstrate elevated left ventricular (LV) myocardial stiffness in comparison with healthy controls as a key marker for future HFpEF.

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