Open AccessEffect of Iron Isomaltoside on Skeletal Muscle Energetics in Patients With Chronic Heart Failure and Iron Deficiency
Author(s) -
Geoff CharlesEdwards,
Nelson Amaral,
Alison Sleigh,
Salma Ayis,
Norman Catibog,
Theresa A. McDonagh,
Mark Monaghan,
George AminYoussef,
Graham J. Kemp,
Ajay M. Shah,
Darlington O. Okonko
Publication year - 2019
Publication title -
circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.795
H-Index - 607
eISSN - 1524-4539
pISSN - 0009-7322
DOI - 10.1161/circulationaha.118.038516
Subject(s) - phosphocreatine , medicine , heart failure , skeletal muscle , transferrin saturation , ejection fraction , ferritin , population , cardiology , clinical endpoint , endocrinology , iron deficiency , anemia , randomized controlled trial , energy metabolism , environmental health
Iron repletion augments exercise capacity in chronic heart failure (HF), but there is a lack of mechanistic data explaining how iron could augment exercise performance despite minimal changes in hemoglobin (Hb). Besides Hb, iron is an obligate component of mitochondrial enzymes that generate cellular energy in the form of adenosine triphosphate and phosphocreatine (PCr). Dynamic phosphorus magnetic resonance spectroscopy is a noninvasive tool that quantifies in vivo muscle energetics by measuring the kinetics of PCr recovery after exertion. We tested the hypothesis that intravenous iron repletion in chronic HF enhances skeletal muscle energetics as reflected by shorter PCr recovery half-times (PCr 1/2 ) on phosphorus magnetic resonance spectroscopy.
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