Placental Growth Factor as an Indicator of Maternal Cardiovascular Risk After Pregnancy | Zendy

Laura Benschop | Zendy; Sarah SchalekampTimmermans | Zendy; Zoe A. Broere-Brown | Zendy; Jeanine E. Roeters van Lennep | Zendy; Vincent W. V. Jaddoe | Zendy; Jolien W. RoosHesselink | Zendy; M. Kamran Ikram | Zendy; Eric A.P. Steegers | Zendy; James M. Roberts | Zendy; Robin E. Gandley | Zendy

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Placental Growth Factor as an Indicator of Maternal Cardiovascular Risk After Pregnancy

Author(s) -

Laura Benschop,

Sarah SchalekampTimmermans,

Zoe A. Broere-Brown,

Jeanine E. Roeters van Lennep,

Vincent W. V. Jaddoe,

Jolien W. RoosHesselink,

M. Kamran Ikram,

Eric A.P. Steegers,

James M. Roberts,

Robin E. Gandley

Publication year - 2019

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circulationaha.118.036632

Subject(s) - medicine , pregnancy , obstetrics , preeclampsia , placental growth factor , gestational age , population , gestational hypertension , quartile , blood pressure , confidence interval , genetics , environmental health , biology

Angiogenic placental growth factor (PlGF) concentrations rise during pregnancy, peaking at the end of midpregnancy. Low PlGF concentrations during pregnancy are associated with pregnancy complications with recognized later-life cardiovascular risk. We hypothesized that low PlGF concentrations, especially in midpregnancy, identify not only a subset of women at risk for pregnancy complications but also women with greater cardiovascular risk factor burden after pregnancy regardless of pregnancy outcome.

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